In the spring issue of Genome, we looked at a technology called fetal cell-free DNA testing (cfDNA), which is a noninvasive procedure that can detect Down syndrome and other chromosomal abnormalities through a sample of blood drawn from the mother. Here’s a look at the four cfDNA tests now available in the United States:
Harmony Prenatal Test: Ariosa Diagnostics’ Harmony Prenatal Test screens for Down syndrome, Patau syndrome, and Edwards syndrome. The test includes an optional analysis of sex chromosome conditions such as Klinefelter syndrome and Turner syndrome. Sex chromosome conditions occur when there is a missing, extra, or incomplete copy of one of the sex chromosomes.
MaterniT21 PLUS: Sequenom’s MaterniT21 PLUS test screens for Down syndrome, Patau syndrome, Edwards syndrome, sex chromosome conditions, and other more rare conditions.
Panorama Prenatal Test: Natera’s Panorama test screens for Down syndrome, Patau syndrome, and Edwards syndrome. It also screens for sex chromosome conditions and triploidy, a rare chromosomal abnormality in which a fetus has an extra set of chromosomes.
Verifi Prenatal Test: The basic version of Illumina’s Verifi test screens for Down syndrome, Patau syndrome, and Edwards syndrome. A wider option is also available to screen for sex chromosome conditions.